منابع مشابه
Modeling and simulation of cancer immunoprevention vaccine
UNLABELLED We present an in silico model that simulates the immune system responses to tumor cells in naive and vaccinated mice. We have demonstrated the ability of this model to accurately reproduce the experimental results. MOTIVATION In vivo experiments on HER-2/neu mice have shown the effectiveness of Triplex vaccine in the protection of mice from mammary carcinoma. Full protection was co...
متن کاملModelling and Simulation of Cancer Immunoprevention Vaccine
We present an in silico model that simulates the immune system responses to tumor cells in naive and vaccinated mice. We have demonstrated the ability of this model to accurately reproduce the experimental results. Motivation: In vivo experiments on HER-2/neu mice have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma. Full protection was conferred using Ch...
متن کاملModelling vaccination schedules for a cancer immunoprevention vaccine
We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs immune system competition activated by tumor vaccine. This model accurately reproduces in-vivo experiments results on HER-2/neu mice treated with the immuno-prevention cancer vaccine (Triplex) for mammary c...
متن کاملImmunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine
Lung cancer remains the leading cause of cancer death worldwide. Mutations in KRAS are detected in up to 30% of lung cancer cases. No effective therapies specifically targeting mutant KRAS have been developed. Vaccination against KRAS mutants is one of the venues of active exploration. The present study evaluated both immunogenicity and antitumor efficacy of a newly formulated multipeptide vacc...
متن کاملCancer Immunoprevention Series Cancer Immunoprevention—The Next Frontier
Cancer immunotherapy is a rapidly developing field, but limited in its success by a high tumor burden and immune tolerance. In contrast, immunoprevention has the potential to prevent cancer before the development of immune tolerance, and to prevent cancer recurrence in the setting of minimal residual disease. Although immunoprevention for viral-induced cancers has been successful in the setting...
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ژورنال
عنوان ژورنال: PULMONOLOGIYA
سال: 2007
ISSN: 2541-9617,0869-0189
DOI: 10.18093/0869-0189-2007-0-4-112-117